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. 2016 Apr 11;35(42):5501–5514. doi: 10.1038/onc.2016.90

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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miR-506 inhibits pancreatic cancer cell proliferation in vitro and in vivo and induces cell cycle arrest. (a, b) The effects of miR-506 on pancreatic cancer cell growth were measured via a CCK-8 assay. The results are presented as the means±s.d. of the values obtained in three independent experiments. Significance was calculated using Student's t-test. (c) Representative graph of tumor growth and the mean tumor weights 30 days after inoculation. (d) Representative immunohistochemical staining of Ki-67-stained cells from the indicated tumors. (e, f) On the basis of flow cytometric analysis, miR-506 overexpression induced via stable lentiviral transfection resulted in a significant increase in the cellular population in the G0/G1 phase but a decrease in those in the S phase in both AsPC-1 and PANC-1 cells. *P<0.05; **P<0.01.