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. 2016 Apr 11;35(42):5501–5514. doi: 10.1038/onc.2016.90

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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miR-506 induces apoptosis and enhances chemosensitivity in pancreatic cancer cells. (a, b) Induction of apoptosis in AsPC-1 and PANC-1 cells transfected with miR-506 mimics or negative control. Compared with the negative control, miR-506 overexpression significantly increased the apoptosis rate in both cell types. (c, d) miR-506 enhanced the chemosensitivity of AsPC-1 and PANC-1 cells to gemcitabine. (e) Western blotting for cleavage of caspase-3 and PARP in NC- or miR-506-transduced AsPC-1 and PANC-1 cells after gemcitabine (20 μM) for 48 h using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a loading control. *P<0.05; **P<0.01.