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. 2016 Apr 11;35(42):5501–5514. doi: 10.1038/onc.2016.90

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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SPHK1 expression in pancreatic cancer and normal pancreatic tissues via immunohistochemistry. (a) IHC staining indicated that SPHK1 expression is upregulated in human pancreatic cancer tissues (clinical stages I–IV) compared with normal pancreatic tissues (left panel: magnification × 100; right panel: magnification × 400). (b) Kaplan–Meier curves of pancreatic cancer patients with low versus high expression levels of SPHK1 (n=388; P<0.001). (c, d) Significance of the difference between the curves of SPHK1 high-expressing and low-expressing patients was compared in clinical stages I−II (c) and clinical stages III−IV (d) patient subgroups. P-values were calculated based on the log-rank test.