Table 2.

Observed meropenem concentrations in serum and cerebrospinal fluid

		Meropenem dosing 1000 mg				Meropenem dosing 2000 mg
Patient number	CrCL (ml/minute)	Cmin (mg/L)	Cmax (mg/L)	Ctrough (mg/L)	Cafter 4h (mg/L)	Cmin (mg/L)	Cmax (mg/L)	Ctrough (mg/L)	Cafter 4h (mg/L)
1	60.7	3.80	N/A	2.00	N/A	10.90	48.60	3.00	4.00
2	156.8	6.90	11.00	N/A	N/A	4.60	26.35	2.75	2.60
3	83.8	4.80	24.10	2.60	1.90	13.80	45.30	2.25	3.45
4	162.9	N/A	N/A	N/A	N/A	1.10	16.40	0.60	0.60
5	217.6	<0.5	5.80	N/A	N/A	2.90	19.40	0.31	0.53
6	124.5	N/A	N/A	N/A	N/A	0.86	19.20	0.76	0.86
7	120.1	N/A	N/A	N/A	N/A	<0.5	15.20	0.43	0.78
8	73.1	N/A	N/A	N/A	N/A	11.00	64.80	3.35	3.00
9	92.1	0.81	12.30	1.08	0.97	3.05	19.65	1.40	1.97
10	96.3	N/A	N/A	N/A	N/A	1.31	33.30	1.62	1.04
11	142.9	N/A	12.82	N/A	1.14	1.02	19.33	0.62	0.74
12	174.1	0,62	5.62	0.39	0.32	N/A	N/A	N/A	N/A
13	100.3	1.38	10.65	1.47	1.15	0.79	19.80	0.87	0.80
14	96.2	N/A	N/A	N/A	N/A	9.83	32.94	2.27	2.19
15	108.8	N/A	N/A	N/A	N/A	1.13	17.51	1.18	0.88
16	125.0	N/A	N/A	N/A	N/A	2.99	27.01	0.92	1.17
17	144.7	N/A	N/A	N/A	N/A	2.44	18.15	0.74	0.58
18	90.5	N/A	20.10	N/A	2.28	7.63	33.80	2.39	1.84
19	131.3	2.50	17.47	0.89	0.83	6.22	26.94	1.79	1.82
20	174.6	N/A	N/A	N/A	N/A	2.63	23.23	1.52	1.58
21	122.5	1.69	10.57	<0.2	0.25	3.65	16.74	0.31	0.44
Median	122.5	1.69	11.65	1.08	1.05	2.95	21.51	1.29	1.10
Minimum	60.7	<0.5	4.40	<0.2	<0.2	<0.5	10.70	<0.2	0.24
Maximum	217.6	7.10	26.60	3.10	2.80	31.40	69.00	4.10	6.20

Abbreviations: C _min Median observed serum trough concentration, C _max Median observed serum peak concentration, C _trough Median observed cerebrospinal fluid concentration at serum trough concentration, C _{after 4h} Median observed cerebrospinal fluid concentration 4 h after serum trough concentration, N/A Not available (patient with only meropenem 1000 mg or only 2000 mg intravenously every 8 h), CrCL Estimated creatinine clearance (calculated using the Cockcroft-Gault equation [16])

Observed meropenem concentrations after 1000 mg or 2000 mg intravenously every 8 h (4-h infusion)