Table 3.

Pharmacokinetic properties of meropenem in serum and cerebrospinal fluid

Patient number	CL (L/h)	Vc (L)	t 1/2 (h)	AUC0–24 serum (mg∙h/L)	AUC0–24 CSF (mg∙h/L)	CSF/serum ratio	t 1/2cb (h)	t 1/2bc (h)
1	7.63	6.45	0.59	768.63	85.53	0.11	3.30	4.62
2	17.88	14.45	0.56	327.09	53.00	0.16	17.33	9.90
3	8.62	14.95	1.20	428.94	48.59	0.11	4.62	3.47
4	20.38	5.05	0.17	300.14	19.37	0.06	13.86	17.33
5	22.87	14.95	0.45	237.60	8.93	0.04	17.33	2.57
6	14.89	5.05	0.24	401.45	18.63	0.05	34.66	69.31
7	23.37	14.95	0.44	258.79	15.02	0.06	34.66	5.78
8	7.88	5.05	0.44	760.20	79.10	0.10	8.66	9.90
9	17.13	14.95	0.60	280.81	26.56	0.09	23.10	17.33
10	11.88	13.75	0.80	489.44	27.25	0.06	69.31	34.66
11	20.63	12.75	0.43	287.15	15.59	0.05	34.66	17.33
12	29.87	9.95	0.23	112.95	10.56	0.09	11.55	9.90
13	15.07	5.05	0.23	234.65	22.10	0.09	23.10	69.31
14	9.63	14.95	1.08	569.59	48.90	0.09	13.86	5.78
15	14.88	5.05	0.24	413.23	25.62	0.06	34.66	69.31
16	17.13	14.95	0.60	337.21	30.99	0.09	23.10	17.33
17	14.98	5.08	0.24	415.22	17.31	0.04	34.66	69.31
18	10.63	5.05	0.33	563.84	42.95	0.08	5.78	8.66
19	13.12	14.95	0.79	394.45	33.99	0.09	34.66	13.86
20	17.13	14.95	0.60	350.22	33.71	0.10	23.10	17.33
21	18.88	14.15	0.52	242.60	7.44	0.03	17.33	1.73
Median	15.07	13.75	0.63	350.22	26.56	0.09	23.10	13.86
Minimum	7.63	5.05	0.17	112.95	7.44	0.03	3.30	1.73
Maximum	29.87	14.95	1.20	768.63	85.53	0.16	69.31	69.31

Abbreviations: CSF Cerebrospinal fluid, CL Median clearance, t _1/2 Median half-life, V _c Median volume of distribution of the central compartment, AUC _0–24 Daily average area under the curve, CSF/serum ratio Cerebrospinal fluid penetration, t _1/2cb Median absorption half-life into cerebrospinal fluid, t _1/2bc Median elimination half-life of cerebrospinal fluid

Individual pharmacokinetic results in serum and CSF obtained using Pmetrics