Table 4.
Population pharmacokinetic mean, median and SD parameters of meropenem obtained using Pmetrics
| Mean | Median | SD | |
|---|---|---|---|
| CL, L/h | 16.045 | 15.025 | ±5.575 |
| Vc, L | 10.949 | 13.736 | ±4.491 |
| K cp, L−1 | 1.562 | 1.248 | ±1.031 |
| K pc, L−1 | 1.686 | 1.898 | ±1.206 |
| K cb, L−1 | 0.052 | 0.026 | ±0.049 |
| K bc, L−1 | 0.092 | 0.054 | ±0.097 |
| VCSF, L | 82.932 | 93.902 | ±18.802 |
Abbreviations: CL Clearance, V c Volume of distribution of the central compartment, V CSF Volume of distribution of the cerebrospinal fluid compartment, K cp, K pc, K bc, K cb Linear transfer rate constants