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. 2016 Oct 24;16:599. doi: 10.1186/s12879-016-1938-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of indomethacin on TB antigen induced FOXP3+CD25++ CD4+ Tregs. PBMCs were obtained from patients with active TB (n = 17) prior to treatment and left unstimulated (unstim) or stimulated for 36 h with ESAT-6 or Ag85 without (open boxes) or with (hatched boxes) addition of indomethacin. The figures show percentages of FOXP3+CD25++ (a) and FOXP3 median fluorescence intensity (MFI) (b) in the CD4+ cells. P- values were calculated by Wilcoxon matched pairs test. Plots are shown as box plots together with individual data points with median, IQR and minimum/maximum values. Significant changes between stimulated samples with and without indomethacin are denoted with p-values in figure. Levels of FOXP3+CD25++ CD4+ T cells and FOXP3 MFI were significantly upregulated upon stimulation with both E6 and Ag85 (p < 0.01, values not shown in figure)