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. 2016 Oct 24;16:599. doi: 10.1186/s12879-016-1938-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of indomethacin on TB antigen induced intracellular cytokines in CD4+ T cells. Total IFN-у+, IL-2+ and TNF-α+ T cell responses in unstimulated (Unstim), ESAT-6 and Ag85 stimulated PBMCs without (open boxes) and with (hatched boxes) indomethacin after 12 h (a, n = 18) and 36 h (b, n = 17) stimulation. PBMCs were obtained from patients with active TB prior to treatment. P- values calculated by Wilcoxon matched pairs test. Plots are shown as box plots with individual data points with median, IQR and minimum/maximum values. Significant changes between stimulated samples with and without indomethacin are denoted with p-values in figure