Table 3. LRC, PFS, and OS, multivariate analysis.

	LRC (n=99; 27 events)		PFS (n=99; 42 events)		OS (n=99; 37 events)
Parameter	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Pathologic CR (yes vs no) If p16 negative	0.31 (0.11-0.88)	.03	0.50 (0.21-1.19)	.12	0.58 (0.22-1.52)	.27
Pathologic CR (yes vs no) If p16 positive	0.68 (0.18-2.59)	.57	0.67 (0.24-1.86)	.44	1.03 (0.34-3.12)	.96
p16 status (positive vs negative) If not pCR	0.13 (0.03-0.48)	.003	0.22 (0.07-0.65)	.007	0.22 (0.07-0.74)	.01
p16 status (positive vs negative) If pCR	0.28 (0.10-0.80)	.02	0.29 (0.13-0.65)	.003	0.40 (0.17-0.94)	.04
T stage (T4 vs T2/3)	1.30 (0.56-2.97)	.54	2.17 (1.15-4.10)	.02	2.38 (1.21-4.67)	.01
N stage (N2b-3 vs N1-2a)	2.77 (0.94-8.18)	.07	1.65 (0.77-3.53)	.20	2.12 (0.90-4.96)	.08
P for interaction between pCR and p16 status	.37		.68		.45

Abbreviations: HR = hazard ratio; LRC = locoregional control; OS = overall survival; pCR = pathologic complete response; PFS = progression-free survival.