Table 8.
Independent Baseline Predictors of ISH Outcomes in Overlap Stents and Nonoverlap Stents for BMS: Multivariable Analysis
| Outcome | Baseline Predictors | Beta (95% CI) | P Value | |
|---|---|---|---|---|
| ISH area, mm2 | Overlap stent | Vessel area (per 1‐mm2 increase) | 0.31 (0.25–0.36) | <0.001 |
| Nonoverlap stent | Vessel area (per 1‐mm2 increase) | 0.086 (0.054–0.12) | <0.001 | |
| Plaque burden behind the stent (per 10% increase) | 0.22 (0.050–0.39) | 0.011 | ||
| ESS (per 1‐Pa decrease) | 0.25 (0.088–0.41) | 0.003 | ||
| %ISH area (%) | Overlap stent | Vessel area (per 1‐mm2 increase) | 1.67 (0.79–2.56) | <0.001 |
| Plaque burden behind the stent (per 10% increase) | 5.61 (2.34–8.88) | 0.001 | ||
| Nonoverlap stent | Plaque burden behind the stent (per 10% increase) | 4.60 (3.44–5.76) | <0.001 | |
| ESS (per 1‐Pa decrease) | 2.69 (1.50–3.88) | <0.001 |
In the multivariable model where ISH area with overlap stent is the dependent variable, vessel area, stent area, plaque area behind the stent, and plaque burden behind the stent at baseline were included as independent variables, because all these variables were predictors of ISH on univariable analyses with P<0.1. In this multivariable model, large vessel area was independently associated with ISH area with overlap. In the multivariable model where ISH area without overlap stent is the dependent variable, vessel area, stent area, plaque area behind the stent, plaque burden behind the stent, and ESS at baseline were included as independent variables. In this multivariable model, large vessel area, plaque burden behind the stent and low ESS were independently associated with ISH area without overlap. In the multivariable model where %ISH area with overlap stent is the dependent variable, vessel area, plaque area behind the stent, and plaque burden behind the stent at baseline were included as independent variables, because all these variables were predictors of %ISH on univariable analyses with P<0.1. In this multivariable model, large vessel area and large plaque behind the stent were independently associated with %ISH area with overlap. In the multivariable model where %ISH area without overlap stent is the dependent variable, vessel area, plaque area behind the stent, plaque burden behind the stent, and ESS at baseline were included as independent variables. In this multivariable model, plaque burden behind the stent and low ESS were independently associated with %ISH area without overlap. ESS indicates endothelial shear stress; ISH, in‐stent hyperplasia.