Table 6.
Matched Treatment Effect Analysis
| IVIG Alone (n=34) | IVIG×2 Doses (n=34) | IVIG+Anti‐inflammatory (n=34) | IVIG×2 Doses and Anti‐inflammatory (n=34) | P Value | |
|---|---|---|---|---|---|
| CAA regression rate | 68% | 68% | 91% | 68% | 0.02 |
| Age at fever onset, y | 1.9 (0.8, 4.4) | 2.0 (0.7, 4.3) | 1.7 (0.6, 4.3) | 1.8 (0.7, 4.0) | 0.94 |
| <1 year | 12 (35%) | 12 (35%) | 12 (35%) | 12 (35%) | 1.0 |
| ≥1 year | 22 (65%) | 22 (65%) | 22 (65%) | 22 (65%) | |
| CAA z‐score at diagnosis | 4.0 (3.5, 5.2) | 4.3 (3.4, 5.2) | 4.1 (3.4, 5.4) | 3.9 (3.5, 5.0) | 0.99 |
| z‐score <5.0 | 25 (74%) | 25 (74%) | 25 (74%) | 25 (74%) | 1.0 |
| z‐score ≥5.0, <10.0 | 6 (18%) | 6 (18%) | 6 (18%) | 6 (18%) | |
| z‐score ≥10.0 | 3 (9%) | 3 (9%) | 3 (9%) | 3 (9%) | |
| Male sex | 23 (68%) | 29 (85%) | 24 (71%) | 24 (71%) | 0.34 |
| Asian race | 10 (29%) | 5 (15%) | 10 (29%) | 9 (26%) | 0.44 |
| Time period of KD | <0.001 | ||||
| 1984–1999 | 7 (21%) | 13 (38%) | 1 (3%) | 5 (15%) | |
| 2000–2009 | 18 (53%) | 19 (56%) | 13 (38%) | 17 (50%) | |
| 2010–2014 | 9 (26%) | 2 (6%) | 20 (59%) | 12 (35%) | |
| Treatment ≥10 days of fever | 5 (21%) | 2 (6%) | 5 (16%) | 3 (10%) | 0.41 |
| Site | <0.001 | ||||
| Boston | 17 (50%) | 28 (82%) | 5 (15%) | 20 (59%) | |
| San Diego | 17 (50%) | 6 (18%) | 29 (85%) | 14 (41%) | |
| CAA location | 0.79 | ||||
| LAD | 20 (59%) | 19 (56%) | 20 (59%) | 17 (50%) | |
| RCA | 5 (15%) | 8 (24%) | 7 (21%) | 5 (15%) | |
| Both LAD and RCA | 9 (26%) | 7 (21%) | 7 (21%) | 12 (35%) |
CAA indicates coronary artery aneurysm; KD, Kawasaki disease; LAD, left anterior descending; RCA, right coronary artery.