Table 1.
Sensitivity and Heterogeneity Analysis of Pooled Relative Risks of SCA, Cardiac Death, and Death From Any Cause Associated With ERP
| SCA | Cardiac Death | Death From Any Cause | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n Studies | RR (95% CI) | I2 (95% CI) | P Valuea | n Studies | RR (95% CI) | I2 (95% CI) | P Valuea | n Studies | RR (95% CI) | I2 (95% CI) | P Valuea | |
| Statistical model | ||||||||||||
| Random effects | 8 | 2.18 (1.29‐3.68) | 91.40 (85.46‐94.91) | <0.001 | 8 | 1.48 (1.06‐2.07) | 84.39 (70.95‐91.61) | <0.001 | 9 | 1.21 (1.02‐1.42) | 90.27 (83.80‐94.16) | <0.001 |
| Fixed effects | 8 | 1.85 (1.63‐2.12) | 8 | 1.19 (1.07‐1.32) | 9 | 1.09 (1.04‐1.14) | ||||||
| Analysis of all studies with | ||||||||||||
| Adjusted risk estimate | 3 | 1.80 (1.54‐2.10) | 97.45 (95.02‐98.69) | <0.001 | 6 | 1.88 (1.31‐2.70) | 75.50 (44.74‐89.14) | 0.001 | 7 | 1.17 (1.02‐1.34) | 73.18 (42.37‐87.52) | 0.001 |
| Large cohortb | 3 | 1.28 (1.08‐1.52) | 0.00 (0.00‐89.60) | 0.78 | 5 | 1.75 (1.11‐2.75) | 63.33 (0.00‐87.63) | 0.04 | 5 | 1.20 (1.003‐1.43) | 87.67 (73.69‐94.23) | <0.001 |
| Analysis of all studies except | ||||||||||||
| One largest study | 7 | 2.41 (1.31‐4.43) | 92.02 (86.12‐95.41) | <0.001 | 7 | 1.52 (1.06‐2.19) | 86.62 (74.60‐92.95) | <0.001 | 8 | 1.26 (1.03‐1.54) | 90.78 (84.24‐94.60) | <0.001 |
| One outlier studyc | 7 | 1.61 (1.27‐2.04) | 46.09 (0.00‐77.28) | 0.09 | 7 | 1.16 (1.04‐1.29) | 80.64 (60.76‐90.45) | <0.001 | 8 | 1.15 (0.97‐1.35) | 90.43 (83.54‐94.43) | <0.001 |
ERP indicates early repolarization pattern; RR indicates relative risk; SCA, sudden cardiac arrest.
a
P‐value for I2.
b
Large‐cohort studies with sample size over 6000.