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. 2016 Aug 30;5(9):e003505. doi: 10.1161/JAHA.116.003505

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Adjusted* restricted cubic spline model showing the hazard ratios (95% CI) for the association of physical activity levels at visit 1 (METS×min/week) and incident ASCVD events, stratified for those without (A) and with (B) a FHx of premature CHD. The solid line represents the hazard ratios and the dashed lines represent the 95% CIs. Knots at 5th, 35th, 65th, and 95th percentiles. Spline centered at score 0. Histogram shows the distribution of METS score. Restricted cubic spline truncated at 1st and 99th percentile of METS score. *Model is adjusted for age, sex, race/center, education, BMI, smoking status, and alcohol intake. ASCVD indicates atherosclerotic cardiovascular disease; BMI, body mass index; CHD, coronary heart disease; FHx, family history; METS, metabolic equivalents of task.