Table 3.

Hazard Ratios and 95% CI for the Association of AHA‐Defined Categories of Physical Activity With Risk for Incident ASCVD Over 21 Years Follow‐Up by Family History Status: The ARIC Study 1987–2012

	Poor	Intermediate	Recommended
No family history of premature CHDe (n=9006)
N events	618	377	550
N total	3065	2329	3612
Incidence ratea	9.8 (9.1, 10.6)	7.7 (6.9, 8.5)	7.2 (6.6, 7.8)
Model 1b	Ref	0.82 (0.72, 0.93)	0.70 (0.62, 0.79)
Model 2c	Ref	0.91 (0.80, 1.04)	0.83 (0.73, 0.94)
Model 3d	Ref	0.89 (0.78, 1.02)	0.83 (0.73, 0.94)
Family history of premature CHDe (n=990)
N events	67	46	65
N total	333	253	404
Incidence ratea	10.1 (7.9, 12.8)	8.7 (6.5, 11.6)	7.6 (6.0, 9.7)
Model 1b	Ref	0.92 (0.63, 1.35)	0.76 (0.54, 1.09)
Model 2c	Ref	1.02 (0.69, 1.51)	0.92 (0.63, 1.33)
Model 3d	Ref	0.98 (0.66, 1.46)	0.80 (0.55, 1.17)

AHA indicates American Heart Association; ARIC, Atherosclerosis Risk in Communities; ASCVD, atherosclerotic cardiovascular disease; BMI, body mass index; CHD, coronary heart disease; FHx, family history; GFR, glomerular filtration rate; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; PA, physical activity.

^aIncidence rate is per 1000 person‐years.

^bModel 1: Age, sex, race/center.

^cModel 2: Model 1+education, BMI, smoking status, and alcohol intake.

^dModel 3: Model 2+additional potential mediating variables (of the association between PA and ASCVD risk)−systolic blood pressure, antihypertensive medication use, diabetes, LDL cholesterol, HDL cholesterol, triglycerides, use of lipid‐lowering medications, and estimated GFR.

^e P‐interaction for FHx (Model 2)=0.680.