Figure 4.

MKEY injection reduced numbers of MoMΦs and their subsets, but not those of MiMΦs, in the ischemic brain 72 hours after stroke. A, Gating strategies to identify MiMΦs and MoMΦs, as well as their subsets, CD45^hi CD11b⁺ CCR2⁺, CD45^hi CD11b⁺Ly6C⁺, CD45^hi CD11b⁺ CX3CR1⁺, CD45^int CD11b⁺ CCR2⁺, and CD45^int CD11b⁺ CX3CR1⁺ in the ischemic brain. B, Quantification of MΦ numbers and their subsets in mice treated with vehicle or MKEY, with sham or stroke surgery. *, **, ***, vs sham surgery, P<0.05, 0.01, 0.001, respectively; ^#, ^##, between the 2 indicated groups, P<0.05, 0.01, respectively.