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. 2016 Sep 26;5(9):e003774. doi: 10.1161/JAHA.116.003774

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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V1‐cal selectively targets TRPV1. A, Experimental protocol for knockout TRPV1 rats (TRPV1 [−/−]). B, Infarct size per area at risk as a percentage for TRPV1 knockout rats. C, Representative images of 2 hearts for each experiment. D, Summary figure: V1‐cal acts as an inhibitor for calcineurin interacting with TRPV1 when TRPV1 is activated by cellular stress. This limits changes in mitochondrial membrane potential and mitigates cardiac reperfusion injury. Mitochondria image adapted from Small et al.27 BL indicates baseline; CON, control; ISC, ischemia; REP, reperfusion; ψm, mitochondrial membrane potential; TRPV1, transient receptor potential vanilloid 1.