Table 1.
Patient and Hospital Characteristicsa
| Prasugrel (n=3123) | Clopidogrel (n=8846) | P‐Value | |
|---|---|---|---|
| Demographics | |||
| Age, y | 57 (50–63) | 61 (53–70) | <0.001 |
| Female, % | 21.5 | 30.2 | <0.001 |
| BMI, kg/m2 | 29.8 (26.5–33.8) | 29.2 (25.8–33.3) | <0.001 |
| Race | <0.001 | ||
| White | 88.1 | 87.9 | |
| Black | 7.6 | 9.3 | |
| Asian | 1.8 | 1.1 | |
| Other | 2.3 | 1.1 | |
| Hispanic | 4.1 | 3.1 | 0.005 |
| Insurance status | <0.001 | ||
| Private | 68.3 | 63.3 | |
| Federal/State | 14.7 | 22.6 | |
| None | 17.0 | 14.1 | |
| Clinical characteristics | |||
| Prior MI, % | 14.6 | 21.3 | <0.001 |
| Prior heart failure, % | 3.0 | 7.0 | <0.001 |
| Prior PCI, % | 17.8 | 23.0 | <0.001 |
| Prior CABG, % | 5.5 | 10.6 | <0.001 |
| Prior stroke/TIA, % | 1.9 | 6.6 | <0.001 |
| Peripheral arterial disease, % | 3.3 | 7.5 | <0.001 |
| Hypertension, % | 61.5 | 68.8 | <0.001 |
| Diabetes mellitus, % | 24.6 | 27.2 | 0.003 |
| Dyslipidemia, % | 62.0 | 66.9 | <0.001 |
| Atrial fibrillation/flutter, % | 2.9 | 5.3 | <0.001 |
| Current/recent smoker | 40.7 | 37.4 | <0.001 |
| Chronic lung disease | 6.6 | 11.0 | <0.001 |
| Dialysis | 0.5 | 1.4 | <0.001 |
| GI/GU bleeding within 6 months | 0.8 | 1.2 | 0.13 |
| Home oral anticoagulation | 1.1 | 3.8 | <0.001 |
| Presentation features | |||
| Transfer in from acute‐care hospital | 26.1 | 43.7 | <0.001 |
| STEMI | 58.6 | 49.3 | <0.001 |
| Cardiac arrest on presentation | 3.6 | 2.7 | 0.02 |
| Heart failure within 2 weeks | 3.6 | 7.7 | <0.001 |
| Cardiogenic shock | 2.5 | 1.9 | 0.06 |
| Heart rate, bpm | 77 (66–90) | 76 (65–88) | 0.02 |
| Systolic blood pressure | 141 (123–160) | 139 (121–158) | 0.002 |
| Creatinine clearance, mL/minb | 78.6 (64.0–95.8) | 70.6 (53.3–89.8) | <0.001 |
| High predicted bleeding risk, % | 38.8 | 48.8 | <0.001 |
| High predicted mortality risk, % | 36.5 | 48.1 | <0.001 |
| Hospital characteristics | |||
| Region (%) | <0.001 | ||
| West | 16.2 | 13.7 | |
| Northeast | 14.6 | 16.0 | |
| Midwest | 34.8 | 39.0 | |
| South | 34.3 | 31.9 | |
| Surgery capability, % | 90.8 | 89.9 | 0.11 |
| Teaching hospital, % | 30.6 | 44.2 | <0.001 |
| Number of hospital beds, median (IQR) | 411 (316–587) | 459 (337–639) | 0.02 |
BMI indicates body mass index; CABG, coronary artery bypass graft surgery; GI, gastrointestinal; GU, genitourinary; IQR, interquartile range; MI, myocardial infarction; PCI, percutaneous coronary intervention; STEMI, ST‐elevation myocardial infarction; TIA, transient ischemic attack.
a
Data are expressed as percentage of patients for categorical variables, median (25th, 75th percentiles) for continuous variables.
b
Creatinine clearance was calculated by the Cockroft‐Gault equation among patients not receiving dialysis.