Table 5.

Influence of Blood Pressure at the Time of Enrollment

	Model 1		Model 2		Model 3		Model 4
	HR (95% CI)	P‐Value	HR (95% CI)	P‐Value	HR (95% CI)	P‐Value	HR (95% CI)	P‐Value
Thromboembolism
Systolic BP
Quartile 1 (<116 mm Hg)	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
Quartile 2 (116–125 mm Hg)	1.00 (0.61–1.64)	0.990	0.97 (0.59–1.59)	0.905	0.98 (0.60–1.60)	0.922	0.96 (0.59–1.58)	0.881
Quartile 3 (126–135 mm Hg)	0.86 (0.52–1.44)	0.565	0.83 (0.49–1.38)	0.465	0.83 (0.50–1.39)	0.480	0.84 (0.50–1.41)	0.417
Quartile 4 (≥136 mm Hg)	1.01 (0.63–1.63)	0.968	0.96 (0.59–1.55)	0.853	0.96 (0.59–1.57)	0.878	0.86 (0.59–1.57)	0.801
Diastolic BP
Quartile 1 (<66 mm Hg)	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
Quartile 2 (66–72 mm Hg)	1.04 (0.63–1.70)	0.885	1.11 (0.68–1.83)	0.668	1.12 (0.68–1.83)	0.657	1.11 (0.68–1.82)	0.681
Quartile 3 (73–79 mm Hg)	0.96 (0.55–1.68)	0.875	1.08 (0.61–1.90)	0.795	1.09 (0.62–1.91)	0.774	1.07 (0.61–1.88)	0.821
Quartile 4 (≥80 mm Hg)	0.96 (0.60–1.55)	0.870	1.15 (0.71–1.87)	0.551	1.16 (0.72–1.88)	0.545	1.16 (0.71–1.88)	0.559
Major hemorrhage
Systolic BP
Quartile 1 (<116 mm Hg)	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
Quartile 2 (116–125 mm Hg)	0.94 (0.57–1.55)	0.810	0.97 (0.59–1.59)	0.893	0.97 (0.59–1.61)	0.915	0.97 (0.59–1.60)	0.905
Quartile 3 (126–135 mm Hg)	1.05 (0.65–1.71)	0.836	1.09 (0.67–1.77)	0.741	1.09 (0.67–1.78)	0.726	1.10 (0.67–1.80)	0.702
Quartile 4 (≥136 mm Hg)	1.30 (0.83–2.05)	0.256	1.36 (0.86–2.15)	0.192	1.38 (0.87–2.19)	0.167	1.37 (0.87–2.18)	0.175
Diastolic BP
Quartile 1 (<65 mm Hg)	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
Quartile 2 (66–72 mm Hg)	1.33 (0.84–2.13)	0.227	1.48 (0.92–2.36)	0.103	1.50 (0.94–2.39)	0.091	1.50 (0.94–2.40)	0.089
Quartile 3 (73–79 mm Hg)	0.87 (0.49–1.54)	0.626	1.03 (0.58–1.84)	0.926	1.05 (0.59–1.88)	0.869	1.06 (0.59–1.89)	0.857
Quartile 4 (≥80 mm Hg)	1.10 (0.69–1.75)	0.680	1.39 (0.87–2.23)	0.167	1.43 (0.89–2.28)	0.140	1.42 (0.88–2.27)	0.148

Model 1: Unadjusted (crude); Model 2: Adjusted for other components of CHADS₂ score (congestive heart failure, age ≥75 y, diabetes mellitus, and history of stroke or TIA); Model 3: Adjusted for other components of CHA₂DS₂‐VASc score (additionally, vascular disease [coronary artery disease], age 65–74 y, and female sex); Model 4: Adjusted for other components of CHA₂DS₂‐VASc score, warfarin use, and antiplatelet use. BP indicates blood pressure; HR, hazard ratio; TIA, transient ischemic attack.