TABLE 2.

Brain Volumes of the Preterm and Fetal Cohorts According to Site and Gestational Age

Variable	Preterm Infants (n = 75)						Fetuses (n = 130)
	Boston (n = 37 [50%])						Boston (n = 55 [42%])
	Washington DC (n = 38 [50%])						Washington DC (n = 75 [58%])
	Boston (n = 10)	DC (n = 17)	P	Boston (n = 27)	DC (n = 21)	P	Boston (n = 40)	DC (n = 35)	P	Boston (n = 15)	DC (n = 40)	P
GA at MRI, wk	30.47 ± 1.8 [27–30.9]	31.92 ± 0.8 [30.6–32.9]	.04	35.61 ± 1.5 [33.1–39]	35.4 ± 1.3 [33.3–37.7]	.61	28.96 ± 1.4 [27–32.42]	30.44 ± 1.7 [27–32.86]	.001	34.73 ± 1 [33–36.57]	35.56 ± 1.7 [33–39]	.03
Cerebrum, mL	160.3 ± 27 [123–205]	163.2 ± 20 [113–199]	.76	203.4 ± 40 [124–276]	195.5 ± 45 [113–289]	.83	138.1 ± 23 [100–290]	156.3 ± 35 [88–231]	.01*	248.4 ± 22 [206–280]	237.6 ± 33 [170–315]	.25
Cerebellum, mL	7.3 ± 1.8 [4–9.4]	7.77 ± 1.6 [5–11]	.48	12.61 ± 2.2 [8–16]	11.91 ± 3.2 [7–18]	.38	6.94 ± 1.6 [4–11]	8.13 ± 2.2 [4–12]	.01*	14.17 ± 1.6 [4–18]	13.91 ± 2.7 [8–20]	.66
Brainstem, mL	3.5 ± 0.4 [3–4]	3.2 ± 0.4 [3–4]	.04*	4.3 ± 0.5 [3–6]	4.4 ± 0.8 [3–6]	.7	2.9 ± 0.4 [2–4]	3.1 ± 0.6 [2–5]	.12	4.7 ± 0.5 [4–6]	4.54 ± 0.7 [4–6]	.33
Total brain volume, mL	171.1 ± 29 [131–218]	174.16 ± 22 [122–214]	.76	236.2 ± 34 [168–296]	237.9 ± 47 [169–311]	.88	148 ± 24 [106–205]	167.6 ± 37 [93–247]	.01*	267.3 ± 23 [222–299]	256.1 ± 36 [183–341]	.27
Intracranial cavity volume, mL	225.8 ± 37 [175–283]	241.8 ± 31 [179–294]	.24	315.37 ± 48 [228–413]	324.64 ± 56 [238–441]	.55	262.7 ± 43 [190–372]	284.1 ± 56 [179–398]	.067	418.2 ± 32 [360–460]	394.8 ± 47 [303–495]	.08

^*Differences are not significant when controlling for gestational age at MRI.