. 2016 Apr 5;85(3):146–158. doi: 10.1159/000444023

Table 3.

Treatment response analyses: linear mixed model examining the effect of the polygenic environmental sensitivity score on treatment response (change in the severity of the primary anxiety disorder)

p value threshold	Overall response				Response to individual CBT				Response to group-based CBT				Response to brief parent-led CBT
	ß	95% CI	p	R², %	ß	95% CI	p	R², %	ß	95% CI	p	R², %	ß	95% CI	p	R², %
0.001	0.01	−0.03 to 0.05	0.699	0.03	−0.01	−0.09 to 0.08	0.865	0.00	0.02	−0.04 to 0.08	0.482	0.08	0.04	−0.06 to 0.15	0.408	0.45
0.01	0.02	−0.02 to 0.06	0.357	0.04	−0.08	−0.17 to 0.01	0.077	0.72	0.04	−0.02 to 0.10	0.182	0.23	0.07	−0.02 to 0.16	0.151	0.80
0.05	0.03	−0.02 to 0.07	0.267	0.05	−0.12	−0.21 to −0.03	0.009	1.62	0.02	−0.04 to 0.08	0.456	0.10	0.18	0.09 to 0.27	6.97 × 10^–5	4.80
0.1	0.02	−0.02 to 0.07	0.339	0.03	−0.11	−0.19 to −0.02	0.014	1.50	0.01	−0.05 to 0.07	0.720	0.04	0.20	0.11 to 0.29	1.92 × 10^–5	5.21
0.2	0.02	−0.02 to 0.07	0.277	0.05	−0.09	−0.18 to −0.01	0.033	1.11	0.01	−0.05 to 0.07	0.841	0.03	0.21	0.12 to 0.30	6.14 × 10^–5	5.77
0.3	0.02	−0.03 to 0.06	0.420	0.02	−0.10	−0.18 to −0.01	0.022	1.23	0.01	−0.06 to 0.06	0.947	0.00	0.20	0.11 to 0.29	1.99 × 10^–5	5.20
0.4	0.02	−0.03 to 0.06	0.485	0.01	−0.10	−0.19 to −0.02	0.017	1.36	0.01	−0.06 to 0.06	0.971	0.01	0.19	0.10 to 0.28	5.78 × 10^–5	4.81
0.5	0.02	−0.03 to 0.06	0.471	0.01	−0.11	−0.19 to −0.02	0.014	1.44	0.01	−0.06 to 0.06	0.918	0.00	0.19	0.10 to 0.29	3.47 × 10^–5	5.14

To account for data collected longitudinally, all models included the random effects of participant and the linear and quadratic effects of time. All models also included sex, age (centred), primary diagnosis (generalized anxiety disorder, social anxiety disorder, specific phobia, separation anxiety disorder or Other anxiety disorder) and treatment type (individual-based CBT, groupbased CBT or brief parent-led CBT). All models included the random effects of trial. Regression weights (ß) significantly greater than zero indicate that this variable is associated with a poorer response following treatment.