Table 7.
Summary of the filter function and the leave-one-out (LOO) experiments. “filter total“, “filter (6/7)“, and “filter (4/5)“ indicate how many models in total and how many models that fulfill 6 out of 7, respectively, 4 out of 5 distance constraints pass the filter; LOO distance and LOO fold indicate the results of LOO in respect to distance fulfillment and structural homology with a Z score of larger than 8; information content measure (sequence separation [aa] / Euclidian separation [Å]) of the distance constraints. XL: Cross-link.
| Laminin β1 | Disulfide 1 |
Disulfide 2 |
Disulfide 3 |
Disulfide 4 |
XL 1 | XL 2 | XL 3 | Mean |
|---|---|---|---|---|---|---|---|---|
| Filter (total) | 484 95.7% |
117 23.1% |
467 92.3% |
47 9.3% |
493 97.4% |
288 56.9% |
435 86.0% |
65% |
| Filter (6/7) | 33 100% |
27 81.8% |
33 100% |
9 27.3% |
33 100% |
33 100% |
33 100% |
84% |
| LOO distance |
3/3 100% |
3/9 33% |
3/3 100% |
3/27 11.1% |
3/3 100% |
3/3 100% |
3/3 100% |
78% |
| LOO fold | 3/3 100% |
6/9 66% |
3/3 100% |
14/27 52% |
3/3 100% |
3/3 100% |
3/3 100% |
88% |
| Information content [Å−1] |
0.38 | 0.69 | 0.23 | 1.54 | 0.37 | 1.90 | 0.47 |
| Laminin γ1 | Disulfide 1 | Disulfide 2 | Disulfide 3 | Disulfide 4 | XL 1 | Mean |
|---|---|---|---|---|---|---|
| Filter (total) | 1226 90.8% |
260 19.3% |
1348 99.9% |
218 16.1% |
1193 88.4% |
63% |
| Filter (4/5) | 291 99.3% |
161 54.9% |
293 100.0 |
148 50.5% |
291 99.3% |
81% |
| LOO distance | 12/14 86% |
12/133 9% |
12/12 100% |
12/145 8% |
12/12 100% |
61% |
| LOO fold | 9/14 64% |
68/133 51% |
9/12 75% |
82/145 57% |
9/12 75% |
64% |
| Information content [Å−1] |
0.77 | 0.62 | 0.23 | 1.31 | 0.43 |