TABLE 6.

Controlled Studies of Testosterone Supplementation in Cognitively Impaired Older Men with Low Testosterone

Authors, Year	N	Mean Age (Range)	Method of T Measurement	Baseline T Level (Cognitive Impairment)	Cognitive Measures*	Supplementation Method	Significant Conclusions
Kenny et al, 2004	11	80 (73–87)	Fasting TT, BT	BT < 128 ng/dL (early cognitive decline)	MEM 1 VS 4, 5 ATT 5, 6	T enanthate intramuscularly 200 mg every 3 weeks for 12 weeks	No significant differences in any tests with T
Tan and Pu, 2003	10	72.4 (68–80)	TT, BT	TT < 250 ng/dL (Alzheimer disease)	GLOB 1, 4 VS 4	T enanthate intramuscularly 200 mg every 2 weeks for 1 year	Nonsignificant improvement in VS 4 with T

^*Table 1 explains the abbreviated cognitive domains and the numbered cognitive tests.

T = testosterone. TT = total testosterone. BT = bioavailable testosterone.