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H334R HDAC8. (a) Superposition of the H334R/Y306F HDAC8‐substrate complex (yellow) and the Y306F HDAC8‐substrate complex (blue; PDB 2V5W). (b) Close‐up view of local structural changes resulting from the H334R substitution; hydrogen bond interactions are shown as dashed black lines. Atomic color codes are as follows: C = yellow, N = blue, O = red, S = green, water molecule = red sphere. Reprinted with permission from ref. 26. Copyright 2014, American Chemical Society.
