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Rescue of catalysis in CdLS HDAC8 mutants by TM251. The activity level for wild‐type HDAC8 in the absence of activator is indicated by a dashed line. The catalytic activities of several mutants can be restored to wild‐type levels in dose‐dependent fashion by TM251. All but the catalytically dead mutants H180R and G304R exhibit at least some tendency for activation. Reprinted with permission from ref. 27. Copyright 2015, American Chemical Society.
