Table 3.

Comparison of changes from baseline to 12 months in the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and total recall of the Buschke Selective Reminding Test (SRT) between metformin and placebo. Crude (unadjusted) analyses are from T-tests. Adjusted analyses are from Analyses of Covariance. The only variable that was adjusted for was the baseline score of the ADAS-cog. Table 1 shows that this was the only baseline variable that was different between the randomization arms.

	Metformin	Placebo	p-value
ADAS-Cog
Baseline	12.0 ± 4.0	14.6 ± 6.1	0.02
Last visit	12.1 ± 3.8	12.8 ± 6.2	0.52
Crude difference	0.0 ± 3.3	-1.98 ± 5.5	0.06
Adjusted difference	-0.5 ± 4.1	-1.4 ± 4.1	0.34
Total recall SRT
Baseline	34.2 ± 7.9	36.1 ± 9.5	0.32
Last visit	43.6 ± 9.1	41.5 ± 8.4	0.31
Crude difference	9.4 ± 8.5	5.7 ± 8.7	0.05
Adjusted difference	9.5 ± 6.1	5.4 ± 6.1	0.05