Log10 PRB (mean ± SD) at 24 h on agar plates containing 1.25 (1.5 for ATCC 27853; a), 2.5 (b) and 5 (c) mg/L tobramycin. This figure shows fAUC/MIC values of 36 (left column), 72 (middle column) and 168 (right column) for the P. aeruginosa ATCC 27853, PAO1 and PAOΔmutS delivered over 1, 4, 10 or 24 h durations of exposure, at initial inocula (cfuo) of 106 and 104 cfu/mL, excluding fAUC/MIC of 36 for ATCC 27853 and fAUC/MIC of 168 for PAOΔmutS for cfuo 104 cfu/mL. When a treatment yielded complete eradication or when there were no colonies on antibiotic-containing agar plates no PRB could be determined, and therefore is shown below the limit of quantification as −9.5 log10.