Table 1.

Tobramycin concentrations (mg/L) and durations of exposure for each studied fAUC/MIC against three strains, ATCC 27853 (MIC 0.5 mg/L), PAO1 (MIC 0.5 mg/L) and PAOΔmutS (MIC 1 mg/L)

Drug exposure duration (h)	fAUC/MIC: 36	fAUC/MIC: 72	fAUC/MIC: 168
ATCC 27853 and PAO1 control	0	0	0
1	18	36	84
4	4.5	9	21
10	1.8	3.6	8.4
24	0.75	1.5	3.5
PAOΔmutS control	0	0	0
1	36	72	168
4	9	18	42
10	3.6	7.2	16.8
24	1.5	3	7