Skip to main content
. 2016 Aug 11;71(11):3157–3167. doi: 10.1093/jac/dkw297

Table 3.

MIC (mg/L) at 24 h [geometric mean (range)] for tobramycin fAUC/MIC of 36, 72 and 168 delivered over various durations of exposure and initial inocula (cfuo) against P. aeruginosa ATCC 27853 (top), PAO1 (middle) and PAOΔmutS (bottom)

Drug exposure duration (h) fAUC/MIC: 36
 fAUC/MIC: 72
 fAUC/MIC: 168
cfuo 1 × 106 cfuo 1 × 104 cfuo 1 × 106 cfuo 1 × 104 cfuo 1 × 106 cfuo 1 × 104
ATCC 27853 control 0.5 (0.5–0.5) ND 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5)
 1 0.5 (0.5–0.5) ND 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5)
 4 0.5 (0.5–0.5) ND 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.25
 10 1.0 (0.5–2.0) ND 0.5 — 0.25 —
 24 4.0 (4.0–4.0) ND 4.0 — — —
PAO1 control 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5)
 1 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.5 (0.5–0.5) 0.7 (0.5–1.0) 0.7 (0.5–1.0) 0.5 (0.5–0.5)
 4 0.7 (0.5–1.0) 0.5 (0.5–0.5) 0.7 (0.5–1.0) 0.7 (0.5–1.0) 0.7 (0.5–1.0) 0.5
 10 2.0 (0.5–8.0) 2.0 (0.5–8.0) 0.25 1.0 0.5 (0.25–1.0) —
 24 5.7 (4.0–8.0) — 4.0 (4–4) — — —
PAOΔmutS control 1.0 (1.0–1.0) 1.0 (1.0–1.0) 1.0 (1.0–1.0) 1.0 (1.0–1.0) 1.0 (1.0–1.0) ND
 1 1.0 (1.0–1.0) 2.8 (2.0–4.0) 1.0 (1.0–1.0) 2.0 (2.0–2.0) 1.0 (1.0–1.0) ND
 4 1.0 (1.0–1.0) 2.0 (2.0–2.0) 1.0 (1.0–1.0) 1.0 (1.0–1.0) 1.0 (1.0–1.0) ND
 10 8.0 (8.0–8.0) 1.0 0.7 (0.5–1.0) — — ND
 24 11.3 (8.0–16.0) 5.7 (4.0–8.0) 5.7 (4.0–8.0) — — ND

ND indicates that this inoculum was not carried out for this strain in this study.

MICs are in bold if they were at least 4-fold above baseline. No range is provided if only one replicate was available. PAOΔmutS at cfuo of 101.2 cfu/mL had MIC 1.0 mg/L with a range 1.0–1.0 mg/L for the growth control, whilst extensive bacterial killing did not allow determination of the MIC for any treated arms.