The mean apparent diffusion coefficients (ADC) values of the patient with high-pressure hydrocephalus and controls. The error bars represent the 95% CI of the group means. Pre, preshunt; Post, postshunt; Con, control group. The ADC values of the 4 regions, R-frontal subcortical (FS), L-FS , R-occipital subcortical (OS), and L-OS, decreased after treatment. The results of intergroup and intragroup statistical analysis are shown as follows: the ADC values of R-FS were significantly different between the controls and the patients with hydrocephalus before treatment. However, the ADC values of R-FS were similar between the controls and the patients after treatment. The ADC values of R-FS in the patients with hydrocephalus were similar before and after treatment. The ADC values of L-FS were significantly different between the controls and the patients with hydrocephalus before treatment. However, the ADC values of L-FS were similar between the controls and the patients after treatment. The ADC values of L-FS in the patients with hydrocephalus were similar before and after treatment. The ADC values of R-OS were markedly different between the controls and the patients with hydrocephalus before treatment. However, the ADC values of R-OS were similar between the controls and the patients after treatment. Moreover, the ADC values of R-OS in the patients with hydrocephalus were significantly different before and after treatment. The ADC values of L-OS were markedly different between the controls and the patients with hydrocephalus before treatment. However, the ADC values of L-OS were similar between the controls and the patients after treatment. Moreover, the ADC values of L-OS in the patients with hydrocephalus were significantly different before and after treatment. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.