Table 1.
Control FVB | Diabetic OVE26 | Diabetic OVE26+sense Rictor | Diabetic OVE26+antisense Rictor | |
---|---|---|---|---|
Glucose level (mM) | 145 ± 10 | 495 ± 10a | 480 ± 15a | 485 ± 18a |
Body weight (g) | 26 ± 1.4 | 18.5 ± 1.3a | 19.5 ± 1.5a | 20 ± 1.5a |
Kidney weight (g) | 0.20 ± 0.02 | 0.28 ± 0.04a | 0.25 ± 0.02a | 0.18 ± 0.07b |
Kidney weight/body weight (g/kg) | 8.1 ± 0.7 | 15.3 ± 0.9a | 13.5 ± 0.6a | 9.3 ± 0.4b |
Urine flow rate (ml/24 h) | 0.7 ± 0.04 | 8.5 ± 0.7a | 8.0 ± 0.5a | 8.5 ± 0.5a |
Values are mean ± standard error from 10 animals for each group (n = 10).
P < 0.05 or 0.001 versus FVB mice; bP < 0.05 or 0.001 versus diabetic OVE26 mice.