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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: JAMA Psychiatry. 2016 Oct 1;73(10):1015–1022. doi: 10.1001/jamapsychiatry.2016.1728

Table 3. Offspring suicide attempt in relation to having at least 1 parent affected by a specific psychiatric diagnosis, by exposure to the specific diagnosis only or additionally to other diagnoses.

Parental psychiatric diagnosis or suicide attempt Exposure
No. IRR (95% CI) a
Specific diagnosis only b Specific diagnosis in addition to other parental disorders Specific diagnosis only b Specific diagnosis in addition to other parental disorders
Any mental disorders 10171c 2115d 2.36 (2.31-2.42)c 4.41 (4.22-4.61)d
Organic mental disorders 132 696 1.65 (1.39-1.95) 3.02 (2.80-3.25)
  Dementia in Alzheimer disease 24 71 1.44 (0.94-2.10) 2.72 (2.13-3.40)
  Vascular dementia 16 25 1.53 (0.90-2.41) 2.01 (1.32-2.91)
Any substance use disorders 1085 4630 2.53 (2.38-2.69) 3.52 (3.41-3.63)
  Alcohol misuse 935 3952 2.45 (2.29-2.61) 3.50 (3.38-3.62)
  Cannabis misuse 11 428 1.54 (0.80-2.64) 4.59 (4.16-5.04)
Broadly-defined schizophrenia e 263 1397 1.77 (1.57-2.00) 2.76 (2.62-2.92)
  Narrowly-defined schizophrenia f 94 474 2.17 (1.76-2.64) 3.06 (2.80-3.35)
  Schizoaffective disorder 7 182 1.74 (0.75-3.36) 2.62 (2.26-3.02)
Mood disorders 858 3263 1.63 (1.52-1.74) 2.71 (2.62-2.81)
  Bipolar disorder 52 496 1.19 (0.90-1.55) 2.09 (1.91-2.28)
  Recurrent depressive disorder 0 1322 2.30 (2.18-2.43)
  Single and recurrent depressive disorders 525 3007 1.71 (1.56-1.86) 2.53 (2.43-2.62)
Anxiety and somatoform disorders 1700 4928 2.21 (2.10-2.32) 3.28 (3.18-3.38)
  Obsessive-compulsive disorder 18 76 1.72 (1.04-2.64) 2.56 (2.03-3.19)
Specific personality disorders 579 4144 2.12 (1.95-2.29) 3.18 (3.08-3.28)
  Borderline type personality disorder 27 362 2.36 (1.58-3.36) 3.65 (3.28-4.04)
  Antisocial personality disorder 60 967 3.06 (2.35-3.90) 4.90 (4.59-5.22)
Attempted suicide 726g 2115d 3.12 (2.89-3.35)g 4.41 (4.22-4.61)d

Abbreviations: ellipses, not applicable; IRR, incidence rate ratio.

a

IRRs adjusted for offspring sex and age, calendar year, and the interactions between these variables. Reference group: neither parent has a mental illness diagnosis or a history of suicide attempt.

b

Not exposed to other parental mental disorders in the defined full spectrum except for the disorder of interest.

c

Offspring with suicide attempt with a history of any parental mental disorder but no history of parental suicide attempt.

d

Offspring with suicide attempt with a history of parental mental disorder and parental suicide attempt.

e

Schizophrenia and related disorders.

f

Schizophrenia only.

g

Offspring with suicide attempt with a history of parental suicide attempt but no history of parental mental disorder.