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qRT-PCR based HCV 1b replicon activity of ProTides 31b and 31e
 | |||||
|---|---|---|---|---|---|
| Cmpd# | R | EC50 (µM)a | EC90 (µM)a | CC50 (µM)a | SI50 |
| 31b |  |
0.01 | 0.13 | 9.98 | 998 |
| 31e |  |
0.01 | 0.08 | 4.59 | 459 |
| 31h |  |
0.02 | 0.13 | 5.28 | 264 |
| 31i |  |
0.04 | 0.69 | 7.27 | 182 |
| 31k |  |
0.04 | 0.69 | 18.37 | 459 |
| Sofosbuvir | Structure - Figure 1 | 0.07 | 0.28 | >5.00 | >71 |
Results are from a single assay generated from quadruplicate assay wells at each concentration
