Table 1. Study participants and deliveries by subtype of VWD.
| Type 1 | Type 2 | Type 3 | Unknown | All | ||
|---|---|---|---|---|---|---|
| Participants | 21 | 9 | 3 | 1 | 34 | |
| Deliveries (%) | 39 | 14 | 4 | 2 | 59 | |
| Mode of delivery (%) | Vaginal | 29 (74.4) | 9 (64.3) | 1(25) | 2 (100) | 41 (69.5) |
| Instrumental vaginal | 4 (10.3) | 2 (14.3) | 1 (25) | - | 7 (11.9) | |
| Caesarean | 6 (15.4) | 3 (21.4) | 2 (50) | - | 11 (18.7) | |
| Induced labour (%) | 7 (17.9) | 5 (35.7) | 1 (25) | - | 13 (22.0) | |
| Maternal age (%) | ≤23 | 4 (10.3) | - | - | - | 4 (6.8) |
| 24–30 | 13 (33.3) | 3 (21.4) | 1 (25) | 1 (50) | 18 (30.5) | |
| 31–37 | 18 (46.2) | 8 (57.1) | 3 (75) | 1 (50) | 30 (50.8) | |
| ≥38 | 4 (10.3) | 3 (21.4) | - | - | 7 (11.9) | |
| Parity (%) | 1 | 20 (51.3) | 7 (50) | 3 (75) | 1 (50) | 31 (52.5) |
| 2 | 13 (33.3) | 4 (28.6) | 1 (25) | 1 (50) | 19 (32.2) | |
| 3 or more | 6 (15.4) | 3 (21.4) | - | - | 9 (15.2) | |
| Birth weight (%) | <2499 | 2 (5.1) | 1 (7.1) | - | - | 3 (5.1) |
| 2500–3999 | 31 (79.5) | 11 (78.6) | 4 (100) | 2 (100) | 48 (81.4) | |
| >4000 | 6 (15.4) | 2 (14.3) | - | - | 8 (13.6) | |
| Gestational age (%) | <36 | 2 (5.1) | - | 1 (25) | - | 3 (5.1) |
| 36–41 | 30 (76.9) | 12 (85.7) | 3 (75) | 2 (100) | 47 (79.7) | |
| >41 | 7 (17.9) | 2 (14.3) | - | - | 9 (15.2) | |
| Obstetric unit in close connection with a coagulation unit (%) | 21 (53.8) | 8 (57.2) | 3 (75) | - | 32 (54.3) | |
| Plasma levels checked in pregnancy (%) | 26 (66.7) | 13 (92.9) | 4 (100) | - | 43 (72.9) | |
| Median VWF:RCo/VWF:GpIb, kIU/L (range) | 0.55(0.08–0.86) | 0.21(0.08–0.68) | 0.08(0.08–0.24) | - | 0.25(0.08–0.86) | |
| Median FVIII:C,kIU/L (range) | 1.07(0.32–2.10) | 0.84(0.63–1.86) | 0.70(0.06–1.17) | - | 0.94(0.06–2.10) | |
| No haemostatic treatment (%) | 13 (33.3) | 1 (7.1) | - | 2 (100) | 16 (27.1) | |
| TXA (%) | 7 (17.9) | 2 (14.3) | - | - | 9 (15.3) | |
| TXA and DDAVP (%) | 11 (28.2) | 1 (7.1) | - | - | 12 (20.3) | |
| TXA and CFC (%) | 8 (20.5) | 10 (71.4) | 4 (100) | - | 22 (37.3) | |
Characteristics regarding mode of delivery, maternal age, parity, birth weight and gestational age, place of delivery, levels of VWF and FVIII in late pregnancy and the haemostatic drug treatment administered during and after delivery.
Abbreviations: VWD = von Willebrand disease; VWF:RCo = von Willebrand factor activity; FVIII:C = Factor VIII activity; TXA = tranexamic acid; DDAVP = desmopressin; CFC = clotting factor concentrate containing VWF and FVIII.