Table 1. Parameter names, optimal values, upper and lower bounds of 95%-confidence intervals and units are given for all kinetic model parameters.

Parameter	$\widehat{\theta }$	conflb	confub	Unit
kATPase	7.94 × 10−2	5.05 × 10−2	1.17 × 10−1	[min−1]
h	1.90	1.39	2.62	[1]
hWSN_H3_mut	4.25	3.02	6.67	[1]
hWSN_H3_wt	2.29	1.72	3.15	[1]
kH+	4.86 × 10−6	3.38 × 10−6	1.01 × 10−5	[mol⋅l−1]
kH+_WSN_H3_mut	2.10 × 10−6	1.79 × 10−6	2.91 × 10−6	[mol⋅l−1]
kH+_WSN_H3_wt	4.34 × 10−6	3.34 × 10−6	8.11 × 10−6	[mol⋅l−1]
kbasal	9.24 × 10−3	5.66 × 10−3	1.31 × 10−2	[min−1]
kdeg	1.89 × 10−1	5.68 × 10−2	∞	[min−1]
kend	9.32 × 10−2	4.28 × 10−2	∞	[min−1]
kfus	3.59 × 10−1	2.79 × 10−1	7.11 × 10−1	[min−1]
kimp	1.00 × 104	0.00	∞	[min−1]
kinhib_100μM	1.84 × 10−4	0.00	∞	[1]
kinhib_40μM	9.89 × 103	0.00	∞	[1]
kτ	1.21	5.04 × 10−1	∞	[min−1]
pHlb	4.46	4.01	4.80	[log10(mol ⋅ l−1)]
pHub	6.20	5.65	6.91	[log10(mol ⋅ l−1)]

The confidence intervals were determined using the profile likelihood approach [44]. The plots of the likelihood profiles are depicted in S4 Fig. For additional parameters and parameter ranges refer to S1 Table.