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Top panel: Effect in individuals with T2DM of dapagliflozin treatment for 2 weeks on ATP synthesis from glutamate (G)/malate (M), pyruvate (Pyr), succinate (SUC) plus rotenone (Rot), and 0.5 μmol/L and 1.0 μmol/L PC. *P < 0.001 vs. baseline. Bottom panel: Correlation between the change in whole-body insulin sensitivity (TGD/SSPI) and the change in ATP synthesis with PC. SSPI, steady-state plasma insulin concentration.
