Figure 7.

S988A-expressing mice have potentiated repair capacity. Diabetic α4(WT) or α4(S988A) mice as indicated were subjected to HLI, and blood perfusion was measured after 3 weeks by LDPI. A: Illustrated are representative scans. NI, nonischemic limb; I, ischemic limb. B: The perfusion in the ischemic limb was normalized to that of the nonischemic limb and a percentage recovery calculated for each mouse. Illustrated are the average recoveries. C and D: Isolated muscles from the ischemic limbs were formalin fixed and sections stained with simplicifolia lectin I (isolectin). Illustrated are representative images (C) and quantitative data (D). The sections were also stained with Sirius Red and illustrated are representative images (E) and quantitative data (F). WT, n = 5; S988A, n = 6. *P < 0.05.