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. 2016 Aug 5;65(11):3289–3300. doi: 10.2337/db16-0114

Table 1.

Plasma, liver, and skeletal muscle parameters in TAZ-deficient mice

TAZ-deficient mice
Genotype NTg Tg NTg Tg NTg Tg
Diet −Dox −Dox +Dox +Dox +Dox +Dox
Age (months) 4 4 4 4 10 10
Plasma parameters
 PC (mg/dL) 72.6 ± 7.8 71.6 ± 8.1 118.6 ± 4.6 108.7 ± 3.3 218.2 ± 8.3 208.8 ± 7.6
 FC (mg/dL) 11.7 ± 1.1 12.0 ± 1.3 22.0 ± 0.7 21.3 ± 0.7 32.0 ± 0.4 30.7 ± 1.3
 CE (mg/dL) 79.8 ± 8.5 85 ± 9 105.2 ± 5.0 89.0 ± 2.3* 165.6 ± 4.6 145.3 ± 5.4*
 TG (mg/dL) 16.4 ± 1.2 18 ± 2.5 59.5 ± 4.2 40.3 ± 5.3* 47.8 ± 4.6 34.6 ± 4.1*
 NEFA (mmol/L) 0.35 ± 0.02 0.33 ± 0.02 0.39 ± 0.03 0.39 ± 0.05 0.38 ± 0.04 0.41 ± 0.04
 Leptin (mg/mL) 0.51 ± 0.02 0.55 ± 0.02 1.25 ± 0.02 0.28 ± 0.01* 23.5 ± 0.02 0.18 ± 0.04*
 ALT (U/L) 18.5 ± 1.0 20.0 ± 0.5 19.6 ± 1.3 15.0 ± 0.3 42.7 ± 5.6 24.3 ± 9.3*
 Glucose (mmol/L) 5.0 ± 0.2 5.9 ± 0.3* 5.8 ± 0.1 6.1 ± 0.2 7.9 ± 0.3 5.7 ± 0.2*
 Insulin (ng/mL) 0.59 ± 0.14 0.49 ± 0.03 0.40 ± 0.05 0.33 ± 0.05 2.17 ± 0.81 0.63 ± 0.25*
 Ketones (mmol/L) 1.16 ± 0.08 1.03 ± 0.07 1.17 ± 0.06 1.03 ± 0.08 1.00 ± 0.11 1.44 ± 0.09*
 TNF-α (pg/mL) BD BD BD BD BD BD
 Adiponectin (μg/mL) 21.3 ± 2.7 20.4 ± 1.2 23.1 ± 1.1 18.4 ± 1.1* 23.5 ± 1.3 17.3 ± 0.6*
Liver parameters
 PC (nmol/mg) 75.3 ± 2.1 80.4 ± 2.2 85.8 ± 1.5 86.7 ± 3.2 66.1 ± 2.2 61.6 ± 1.2
 PE (nmol/mg) 33.7 ± 1.5 40.0 ± 2.1* 42.9 ± 1.1 45.4 ± 2.0 30.7 ± 1.1 34.4 ± 1.1*
 PS (nmol/mg) 4.4 ± 0.2 5.0 ± 0.3 4.8 ± 0.2 5.4 ± 0.2 5.3 ± 0.2 6.2 ± 0.3*
 PI (nmol/mg) 15.5 ± 0.7 15.9 ± 0.4 15.5 ± 0.7 15.9 ± 0.4 13.5 ± 0.4 13.2 ± 0.3
 FC (μg/mg) 7.6 ± 0.8 7.5 ± 0.3 7.9 ± 0.2 8.1 ± 0.1 13.2 ± 1.0 12.6 ± 0.6
 CE (μg/mg) 3.9 ± 0.6 4.2 ± 0.4 3.6 ± 0.1 3.6 ± 0.1 11.7 ± 0.8 7.3 ± 1.0*
 TG (μg/mg) 222.2 ± 17.8 238.6 ± 23.2 118.1 ± 12.7 92.7 ± 14.6 677.01 ± 68.1 125.6 ± 24.9*
 NEFA (μg/mg) ND ND ND ND 2.3 ± 0.3 1.4 ± 0.2*
 SM (μg/mg) 9.6 ± 1.0 8.2 ± 1.4 8.1 ± 0.3 8.2 ± 0.2 8.5 ± 0.6 8.6 ± 0.5
Skeletal muscle parameters
 PC (nmol/mg) 20.3 ± 2.8 31.4 ± 3.2 31.4 ± 2.2 24.1 ± 1.9 32.3 ± 2.6 25.8 ± 2.2
 PE (nmol/mg) 4.9 ± 0.6 8.5 ± 0.3* 9.7 ± 1.7 7.5 ± 0.9 10.4 ± 0.8 8.9 ± 0.7
 PI (nmol/mg) 3.4 ± 0.2 3.1 ± 0.3 3.3 ± 0.1 3.4 ± 0.5 3.2 ± 0.1 2.8 ± 0.1
 FC (μg/mg) 1.1 ± 0.2 1.6 ± 0.2 1.3 ± 0.2 1.2 ± 0.1 1.4 ± 0.1 1.4 ± 0.1
 TG (μg/mg) 31.1 ± 6.0 37.2 ± 8.8 53.2 ± 12.1 13.8 ± 4.5* 213.5 ± 16.6 28.3 ± 3.1*

Data are means ± SEMs (n = 5–17). ALT, alanine aminotransferase; BD, below detection; CE, cholesteryl ester; FC, unesterified free cholesterol; ND, not determined; NEFA, nonesterified fatty acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosphatidylserine; SM, sphingomyelin; TNF, tumor necrosis factor.

*P < 0.05 compared with NTg age-matched mice fed an identical diet.