Table 1.
Plasma, liver, and skeletal muscle parameters in TAZ-deficient mice
TAZ-deficient mice | ||||||
---|---|---|---|---|---|---|
Genotype | NTg | Tg | NTg | Tg | NTg | Tg |
Diet | −Dox | −Dox | +Dox | +Dox | +Dox | +Dox |
Age (months) | 4 | 4 | 4 | 4 | 10 | 10 |
Plasma parameters | ||||||
PC (mg/dL) | 72.6 ± 7.8 | 71.6 ± 8.1 | 118.6 ± 4.6 | 108.7 ± 3.3 | 218.2 ± 8.3 | 208.8 ± 7.6 |
FC (mg/dL) | 11.7 ± 1.1 | 12.0 ± 1.3 | 22.0 ± 0.7 | 21.3 ± 0.7 | 32.0 ± 0.4 | 30.7 ± 1.3 |
CE (mg/dL) | 79.8 ± 8.5 | 85 ± 9 | 105.2 ± 5.0 | 89.0 ± 2.3* | 165.6 ± 4.6 | 145.3 ± 5.4* |
TG (mg/dL) | 16.4 ± 1.2 | 18 ± 2.5 | 59.5 ± 4.2 | 40.3 ± 5.3* | 47.8 ± 4.6 | 34.6 ± 4.1* |
NEFA (mmol/L) | 0.35 ± 0.02 | 0.33 ± 0.02 | 0.39 ± 0.03 | 0.39 ± 0.05 | 0.38 ± 0.04 | 0.41 ± 0.04 |
Leptin (mg/mL) | 0.51 ± 0.02 | 0.55 ± 0.02 | 1.25 ± 0.02 | 0.28 ± 0.01* | 23.5 ± 0.02 | 0.18 ± 0.04* |
ALT (U/L) | 18.5 ± 1.0 | 20.0 ± 0.5 | 19.6 ± 1.3 | 15.0 ± 0.3 | 42.7 ± 5.6 | 24.3 ± 9.3* |
Glucose (mmol/L) | 5.0 ± 0.2 | 5.9 ± 0.3* | 5.8 ± 0.1 | 6.1 ± 0.2 | 7.9 ± 0.3 | 5.7 ± 0.2* |
Insulin (ng/mL) | 0.59 ± 0.14 | 0.49 ± 0.03 | 0.40 ± 0.05 | 0.33 ± 0.05 | 2.17 ± 0.81 | 0.63 ± 0.25* |
Ketones (mmol/L) | 1.16 ± 0.08 | 1.03 ± 0.07 | 1.17 ± 0.06 | 1.03 ± 0.08 | 1.00 ± 0.11 | 1.44 ± 0.09* |
TNF-α (pg/mL) | BD | BD | BD | BD | BD | BD |
Adiponectin (μg/mL) | 21.3 ± 2.7 | 20.4 ± 1.2 | 23.1 ± 1.1 | 18.4 ± 1.1* | 23.5 ± 1.3 | 17.3 ± 0.6* |
Liver parameters | ||||||
PC (nmol/mg) | 75.3 ± 2.1 | 80.4 ± 2.2 | 85.8 ± 1.5 | 86.7 ± 3.2 | 66.1 ± 2.2 | 61.6 ± 1.2 |
PE (nmol/mg) | 33.7 ± 1.5 | 40.0 ± 2.1* | 42.9 ± 1.1 | 45.4 ± 2.0 | 30.7 ± 1.1 | 34.4 ± 1.1* |
PS (nmol/mg) | 4.4 ± 0.2 | 5.0 ± 0.3 | 4.8 ± 0.2 | 5.4 ± 0.2 | 5.3 ± 0.2 | 6.2 ± 0.3* |
PI (nmol/mg) | 15.5 ± 0.7 | 15.9 ± 0.4 | 15.5 ± 0.7 | 15.9 ± 0.4 | 13.5 ± 0.4 | 13.2 ± 0.3 |
FC (μg/mg) | 7.6 ± 0.8 | 7.5 ± 0.3 | 7.9 ± 0.2 | 8.1 ± 0.1 | 13.2 ± 1.0 | 12.6 ± 0.6 |
CE (μg/mg) | 3.9 ± 0.6 | 4.2 ± 0.4 | 3.6 ± 0.1 | 3.6 ± 0.1 | 11.7 ± 0.8 | 7.3 ± 1.0* |
TG (μg/mg) | 222.2 ± 17.8 | 238.6 ± 23.2 | 118.1 ± 12.7 | 92.7 ± 14.6 | 677.01 ± 68.1 | 125.6 ± 24.9* |
NEFA (μg/mg) | ND | ND | ND | ND | 2.3 ± 0.3 | 1.4 ± 0.2* |
SM (μg/mg) | 9.6 ± 1.0 | 8.2 ± 1.4 | 8.1 ± 0.3 | 8.2 ± 0.2 | 8.5 ± 0.6 | 8.6 ± 0.5 |
Skeletal muscle parameters | ||||||
PC (nmol/mg) | 20.3 ± 2.8 | 31.4 ± 3.2 | 31.4 ± 2.2 | 24.1 ± 1.9 | 32.3 ± 2.6 | 25.8 ± 2.2 |
PE (nmol/mg) | 4.9 ± 0.6 | 8.5 ± 0.3* | 9.7 ± 1.7 | 7.5 ± 0.9 | 10.4 ± 0.8 | 8.9 ± 0.7 |
PI (nmol/mg) | 3.4 ± 0.2 | 3.1 ± 0.3 | 3.3 ± 0.1 | 3.4 ± 0.5 | 3.2 ± 0.1 | 2.8 ± 0.1 |
FC (μg/mg) | 1.1 ± 0.2 | 1.6 ± 0.2 | 1.3 ± 0.2 | 1.2 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 |
TG (μg/mg) | 31.1 ± 6.0 | 37.2 ± 8.8 | 53.2 ± 12.1 | 13.8 ± 4.5* | 213.5 ± 16.6 | 28.3 ± 3.1* |
Data are means ± SEMs (n = 5–17). ALT, alanine aminotransferase; BD, below detection; CE, cholesteryl ester; FC, unesterified free cholesterol; ND, not determined; NEFA, nonesterified fatty acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosphatidylserine; SM, sphingomyelin; TNF, tumor necrosis factor.
*P < 0.05 compared with NTg age-matched mice fed an identical diet.