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A proposed model for TBC1D20 function during autophagy. TBC1D20 mediates maturation of autophagosomes via its RAB1B GAP function, a process required for the fusion of autophagosomes with late endosomes to form amphisomes as well as a direct fusion of autophagosomes with lysosomes to form autolysosomes, thereby facilitating autophagic flux and delivery and subsequent degradation of autophagic cargo in autolysosomes.
