Figure 1.

Heterogeneous expression of core autophagy genes in melanoma and a broad spectrum of cancer types. GSEA heat map showing a differential enrichment of the indicated autophagy genes across the Cancer Cell Line Encyclopedia (CCLE), which encompasses a total of 917 cell lines of indicated tumor types. The Lysosome Gene Ontology gene set (GO:0005764), a melanoma-enriched feature, is included to visualize the distinct regulation of lysosomal-associated degradative processes. FDR values for the autophagy vs the lysosome GO set are indicated on the right.