Table 2.

Apparent diffusion coefficient ADC(0,800) and parameters D′ and f′ estimated by using the IVIM model before and after therapy with changes

	LDT	LDCE	LDT	ADC(0,800)			D′			f′
	(%)			(10−6 mm2/s)			(10−6 mm2/s)
	rdiff	rdiff	rdiff2	pre	post	diff	pre	post	diff	pre	post	diff
Group A
Mean	−16	−58	−29	1,067	1,358	291	953	1,323	370	0.087	0.052	−0.035
SD	9	32	15	262	258	213	218	263	229	0.042	0.037	0.036
N	17	17	16	17	17	17	17	17	17	17	17	17
Min	−37	−100	−60	691	928	−61	592	864	1	0.032	0.002	−0.136
Max	−5	−14	−10	1,591	1,822	641	1,317	1,823	693	0.192	0.152	0.026
Group B
Mean	5	2	2	1,190	1,207	17	1,067	1,103	37	0.094	0.088	−0.006
SD	7	6	12	260	285	205	233	259	167	0.036	0.044	0.034
N	14	9	11	14	14	14	14	14	14	14	14	14
Min	−4	−2	−16	775	748	−249	731	685	−205	0.045	0.020	−0.033
Max	26	19	31	1,774	1,721	310	1,628	1,633	280	0.170	0.170	0.072
P-value				ns	ns	0.00190	ns	0.02902	0.00016	ns	0.01706	0.04384

Notes: P-values are related to differences between Groups A (responders) and B (nonresponders). Group A includes all HCCs with definite reduction of LDT and Group B all other cases. Pre- and postvalues of ADC(0,800), D′, and f′ differed only within Group A (P=0.00004, P=0.00001, and P=0.00094, respectively). Moreover, the LDT changes at first follow up differed from those at second follow up and the ADC(0,800) changes differed from the D′ changes only within Group A (P=0.00008 and P=0.00018, respectively).

Abbreviations: ADC, apparent diffusion coefficient; diff, absolute difference of postvalues (at first follow up) minus prevalues; HCC, hepatocellular carcinoma; IVIM, intravoxel incoherent motion; LDCE, longest diameter of the region with contrast enhancement; LDT, longest diameter of the whole tumor; ns, not significant; post, at the first follow up; pre, before therapy; rdiff, relative difference at the first follow up; rdiff2, relative difference at the second follow up; SD, standard deviation.