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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Dec 10;36(2):389–397. doi: 10.1161/ATVBAHA.115.306112

Figure 4. Oxidized LDL exposure leads to expression of PD-1 by CD8 T cells in vitro.

Figure 4

PBMC from healthy volunteers were stimulated for 18 hours in media alone (NS), with lipopolysaccharide (LPS: 20ng/ml), thrombospondin (TSP-1: 10ug/ml), low density lipoprotein (LDL: 100ug/ml), or oxidized LDL (10ug/ml, 100ug/ml) and the expression of PD-1 by CD8 T cells was determined by flow cytometry. Representative flow histograms illustrating PD-1 expression by CD8 T cells (A) and aggregate percentages of PD-1+ CD8 T cells are shown (B). (Repeated measures ANOVA, Bonferroni post hoc tests; ***: p<0.001)