Figure 1.
Dopaminergic Negative Feedback Regulating Insulin Secretion Schematic diagram of a β-cell expressing the molecular machinery for dopamine synthesis, storage, and secretion. The dopamine receptor D2R mediates the inhibition of glucose-stimulated insulin secretion. AADC, l-amino acid decarboxylase; DA, dopamine; GSIS, glucose-stimulated insulin secretion; INS, insulin; MAO, monoamine oxidase; LAAT, l-type amino acid transporter; D2R, dopamine 2-like receptors; dopac, 3,4-dihydroxyphenylacetic acid.