Table 3.
Mean (SEM) cardiovascular, impedance-derived hemodynamic and neuroendocrine stress testing levels in women endorsing being “not at all” versus “quite a bit” or “extremely” bothered by vasomotor symptoms (VMS).
| Hot Flash Bother |
Night Sweat Bother |
|||
|---|---|---|---|---|
| ‘Not at all’ (n = 63) | ‘Quite a bit’ or ‘Extremely’ (n = 56) | Not at all (n = 70) | ‘Quite a bit’ or ‘Extremely’ (n = 51) | |
| Systolic blood pressure (mmHg) | 128.0 (122.6-133.5) | 128.3 (123.6-133.0) | 129.9 (125.9-133.9) | 126.9 (122.3-131.6) |
| Diastolic blood pressure (mmHg) | 78.6 (75.3-81.9) | 77.8 (75.0-80.6) | 78.6 (76.2-80.9) | 77.8 (75.1-80.5) |
| heart rate (bpm) | 75.1 (71.3-78.8) | 74.1 (70.9-77.3) | 77.1 (74.3-79.8) | 74.4 (71.3-77.6) |
| cardiac index (l/min) | 4.1 (3.8-4.5) | 3.5 (3.3-3.8)** | 4.0 (3.7-4.3) | 3.7 (3.4-4.0) |
| vascular resistance index (dyne s cm−5 M2) | 1853.1 (1634.5-2100.9) | 2166.1 (1945.7-2411.5)* | 1918.1 (1748.1-2104.6) | 2031.0 (1824.4-2261.1) |
| stroke volume index (ml/beat per M2) | 56.3 (49.8-63.5) | 48.2 (43.4-53.5)* | 53.3 (48.7-58.4) | 51.1 (46.0-56.7) |
| norepinephrine (pg/ml) | 421.0 (374.3-473.4) | 456.2 (411.4-505.8) | 408.5 (373.5-446.7) | 457.6 (413.8-506.0) |
| epinephrine (pg/ml) | 61.7 (48.0-79.3) | 41.7 (33.4-52.1)* | 53.9 (44.2-65.7) | 42.5 (33.9-53.3) |
| Cortisol (pg/ml) | 7.4 (6.4-8.5) | 8.6 (7.6-9.7)# | 6.5 (5.8-7.3) | 8.3 (7.2-9.4)* |
| IL-6 (pg/ml) | 1.1 (0.9-1.2) | 1.2 (1.1-1.4)# | 1.2 (1.0-1.3) | 1.3 (1.1-1.4) |
#
p<.10
*
p<.05
**
p<.01
Although hot flash severity was treated as a continuous variable in the following repeated measures analyses, it has been treated as a dichotomous variable for illustration purposes.