Table 1.
UCSF Mother-Child Immunogenetic Study (MCIS) and Inova Translational Medicine Institute (ITMI) participant characteristics
| Cases | Controls | |
|---|---|---|
| Mean ± SD or N (%) | Mean ± SD or N (%) | |
| Mothers, n | 219 | 1,085 |
| Age at study enrollment 1, 2 | 53.8±11.0 | 37.7±10.4 |
| Number of live births 2 | 2.3±1.2 | 1.9±1.0 |
| Ever smoker 2 | 103 (47.0) | 271 (25.0) |
| Age at diagnosis, per medical records | 38.6±12.6 | -- |
| Autoantibodies 3 | ||
| Anti-dsDNA | 87 (39.7) | -- |
| Missing | 7 (3.2) | |
| Anti-Ro | 65 (29.7) | -- |
| Missing | 13 (5.9) | |
| Anti-La | 28 (12.8) | -- |
| Missing | 14 (6.4) | |
| Anti-Sm | 20 (9.1) | -- |
| Missing | 14 (6.4) | |
| Anti-RNP | 33 (15.1) | -- |
| Missing | 19 (8.7) |
1
ITMI controls age at study enrollment is mother's age at birth of child.
2
p-value <0.001 for the difference between cases and controls.
3
Patients may have more than one autoantibody.