Table 2.
Association between carrying 1 or more known DRB1 risk alleles and systemic lupus erythematosus among mothers in the Mother-Child Immunogenetic Study (MCIS)
| HLA-DRB1 alleles (Mothers) | N =1,304 (cases/controls) | SLE OR (95% CI) 1 | Bonferroni corrected p-value |
|---|---|---|---|
| *03:01 | |||
| None | 139/832 | Reference | 0.0004 |
| 1 or 2 | 80/253 | 1.9 (1.4-2.6) | |
| *15:01 | |||
| None | 156/831 | Reference | 0.36 |
| 1 or 2 | 63/254 | 1.3 (1.0-1.8) | |
| *08:01 | |||
| None | 201/1,038 | Reference | 0.07 |
| 1 or 2 | 18/47 | 2.0 (1.1-3.5) | |
| *04:01 | |||
| None | 177/920 | Reference | 0.56 |
| 1 or 2 | 42/165 | 1.3 (0.9-1.9) |
1
OR = odds ratio; 95% CI = 95% confidence interval for the association between carrying one or more of each listed DRB1 allele compared to none and SLE among mothers.