Table 3.
Association between children carrying DRB1 alleles of interest and mothers’ systemic lupus erythematosus status
| HLA-DRB1 allele-positive children | N =1,304 (cases/controls) | SLE (mother) OR (95% CI) 1 | Bonferroni corrected p-value |
|---|---|---|---|
| *03:01 | |||
| None | 147/836 | Reference | 1.0 |
| 1 or more | 72/249 | 1.2 (0.8-1.7) | |
| *15:01 | |||
| None | 141/787 | Reference | 0.48 |
| 1 or more | 78/298 | 1.3 (0.9-1.9) | |
| *08:01 | |||
| None | 204/1,035 | Reference | 1.0 |
| 1 or more | 15/50 | 1.0 (0.5-2.2) | |
| *04:01 | |||
| None | 168/941 | Reference | 0.004 |
| 1 or more | 51/144 | 2.1 (1.4-3.1) |
1
OR = odds ratio; 95% CI = 95% confidence interval for the association between having one or more children with the specified DRB1 alleles compared to none and SLE among mothers. Each model is adjusted for number of live births and maternal carrier status of the same allele.