Table 4.
Association between children carrying DRB1 alleles of interest and mothers’ systemic lupus erythematosus status among allele-negative mothers
| HLA-DRB1 allele-positive children | N Allele-negative mothers (cases/controls) | SLE (mother) OR (95% CI) 1 | Bonferroni corrected p-value |
|---|---|---|---|
| *03:01 | |||
| None | 118/729 | Reference | 1.0 |
| 1 or more | 21/103 | 1.1 (0.7-1.9) | |
| *15:01 | |||
| None | 127/688 | Reference | 1.0 |
| 1 or more | 29/143 | 1.0 (0.7-1.6) | |
| *08:01 | |||
| None | 195/1,014 | Reference | 1.0 |
| 1 or more | 6/24 | 1.4 (0.5-3.4) | |
| *04:01 | |||
| None | 155/852 | Reference | 0.08 |
| 1 or more | 22/66 | 1.9 (1.1-3.2) |
1
OR = odds ratio; 95% CI = 95% confidence interval for the association between having one or more children with the specified DRB1 alleles compared to none and SLE among mothers. Each model is for mothers negative for the allele and is adjusted for number of live births.