Table 1.
Univariate comparison between those with and without severe ROP
| No severe ROP n=50 |
Severe ROP n=13 |
P value | |
|---|---|---|---|
| Perinatal factors | |||
| Any antenatal steroid exposure, n(%) | 38 (76) | 10 (77) | 1.0 |
| Complete antenatal steroid treatmenta, n (%) |
19 (38) | 8 (62) | 0.21 |
| Magnesium sulfate exposure, n(%) | 24 (48) | 8 (61) | 0.54 |
| Vaginal delivery, n (%) | 21 (42) | 3 (23) | 0.34 |
| Chorioamnionitisb, n (%) | 17 (34) | 6 (46) | 0.53 |
| Apgar score at 5 m, median (range) | 6 (1–9) | 5 (3–8) | 0.17 |
| Patient factors | |||
| CRIB-II score, median (range) | 10 (5–14) | 13 (10–15) | <0.01* |
| EGA, mean (SD), weeks | 26.0 (1.5) | 25.0 (1.3) | 0.02* |
| Birth weight, mean (SD), grams | 961.5 (177.9) | 656.5 (110.4) | <0.01* |
| Postnatal age at recording start, median (range), hours |
15.6 (4–23) | 17.6 (5–19) | 0.329 |
| IUGR status, n(%) | 4 (8) | 3 (23) | 0.07 |
| Male sex, n(%) | 29 (58) | 10 (76) | 0.33 |
| Caucasian race, n (%) | 23 (46) | 9 (69) | 0.21 |
| Prophylactic surfactant, n(%) | 50 (100) | 13 (100) | 1.0 |
| Mechanical ventilation beyond 7 days of life, n (%) |
30 (60) | 8 (62) | 1.0 |
| Highest stage ROP (either eye), median (range) |
1 (0–2) | 3 (1–3) | <0.01* |
| Outcome factors | |||
| BPDc, (n%) | 32 (64) | 13 (100) | 0.01* |
| Grade I/II IVH, n (%) | 6 (12) | 3 (23) | 0.38 |
| Inotrope exposure, n (%) | 5 (10) | 7 (54) | <0.01* |
| Bevacizumab exposure, n(%) | 0 (0) | 3 (23) | <0.01* |
| Average % FiO2 during the first 96h, mean (SEM) |
29.3 (1.3) | 29.6 (2.0) | 0.74 |
| Average % SctO2 during the first 96h, mean (SEM) |
72.3 (0.6) | 71.5 (1.5) | 0.831 |
| Percentage of recorded FTOE values below threshold, mean (SEM) |
|||
| <20% | 34 (4) | 33 (8) | 0.85 |
| <15% | 10 (2) | 12 (4) | 0.73 |
| <10% | 2 (1) | 3 (1) | 0.38 |
| Percentage of recorded SpO2 values above threshold, mean (SEM) |
|||
| >90% | 84 (2) | 81 (3) | 0.37 |
| >93% | 55 (3) | 51 (6) | 0.60 |
| >95% | 33 (3) | 30 (7) | 0.69 |
a
Defined as two doses of betamethasone given over a 48 h period.
b
Based on histological examination of the placenta.
c
Defined as need for supplemental oxygenation after 36 weeks postmenstrual age.
*
Denotes significance at p ≤ 0.05.
Comparisons were made using Mann–Whitney U-test for continuous variables or Fisher’s Exact Test (two-sided) for categorical variables. Reported p values are unadjusted.