Table 3.
Pediatric PROMIS short form domain score† change across visits and relationship to change in cSLE, health status and disease activity
| Variable/Category | Anger | Anxiety | Depressive Symptoms | Fatigue | Mobility | Upper Extremity Function | Pain Interefence | Peer Relationships | |
|---|---|---|---|---|---|---|---|---|---|
| Change in cSLE (GRC-MD1) | Better | −3.2(1.4)* | −2.7 (1.3)* | −1.3 (1.4) | −2.6 (1.6) | 2.9 (1.2)* | 2.8 (1.5) | −3.2 (1.3)* | −0.0 (1.5) |
| Same | −0.5 (1.3) | 1.0 (1.1) | 1.7 (1.2) | 0.3 (1.4) | 0.5 (1.1) | 0.1 (1.3) | −0.1 (1.2) | −0.3 (1.4) | |
| Worse | 0.4 (2.0) | 1.1 (1.8) | 2.0 (1.9) | −0.2 (2.1) | −4.0 (1.7)* | −1.4 (2.0) | 1.3 (1.8) | −0.9 (2.1) | |
|
| |||||||||
| Change in Health (GRC-MD2) | Better | −3.3 (1.4)* | −3.1 (1.3)* | −1.4 (1.4) | −2.5 (1.5) | 3.1 (1.2)* | 2.4 (1.5) | −3.3 (1.3)* | −0.6 (1.5) |
| Same | −0.3 (1.3) | 1.3 (1.2) | 2.1 (1.2) | 0.6 (1.4) | −0.5 (1.1) | −0.4 (1.3) | 0.2 (1.2) | 0.1 (1.4) | |
| Worse | 0.4 (1.9) | 1.2 (1.7) | 1.6 (1.8) | −0.9 (2.0) | −1.7 (1.6) | 0.1 (1.9) | 0.9 (1.7) | −0.9 (2.0) | |
|
| |||||||||
| Change in MD-global (MD-VAS) | Better | −5.2 (1.9)* | −1.7 (1.7) | −1.6 (1.7) | −1.2 (2.1) | 2.4 (1.6) | 2.2 (1.5) | −2.5 (1.9) | −1.9 (2.1) |
| Same | −0.5 (1.0) | 0.6 (0.9) | 0.8 (0.9) | −0.4 (1.1) | −0.1 (0.9) | −0.4 (0.8) | 0.4 (1.0) | −0.5 (1.1) | |
| Worse | −0.9 (2.5) | 1.9 (2.2) | 5.0 (2.3)* | −1.4 (2.7) | −0.8 (2.1) | 2.9 (1.8) | −1.2 (2.4) | 3.1 (2.6) | |
|
| |||||||||
| Change in SLEDAI | Better | −4.1 (1.8)* | −0.7 (1.6) | −0.8 (1.7) | −1.7 (2.0) | 4.2 (1.5)* | 1.8 (1.4) | −2.2 (1.8) | −2.0 (2.0) |
| Same | −0.6 (1.1) | 0.9 (0.9) | 1.7 (1.0) | −0.2 (1.2) | −0.8 (0.9) | −0.2 (0.8) | 0.6 (1.0) | −0.3 (1.1) | |
| Worse | −1.6 (2.1) | −1.1 (1.8) | −0.3 (1.9) | −0.3 (2.3) | −1.7 (1.8) | 0.8 (1.6) | −1.1 (2.1) | 0.2 (2.3) | |
|
| |||||||||
| Change in BILAGE | Better | −2.2 (1.5) | −1.0 (1.3) | 1.3 (1.4) | 0.7 (1.7) | 3.1 (1.3)* | 3.1 (1.1)* | −3.3 (1.5)* | −2.2 (1.6) |
| Same | −1.2 (1.2) | 1.2 (1.1) | 1.0 (1.1) | 0.0 (1.3) | −1.0 (1.0) | −1.0 (0.9) | 1.0 (1.2) | −0.6 (1.3) | |
| Worse | −1.2 (1.8) | −0.2 (1.6) | −0.1 (1.6) | −3.2 (1.9) | −1.7 (1.5) | −0.4 (1.3) | 1.4 (1.7) | 1.7 (1.9) | |
†
Values are T-score means (Standard Error) across visits – pooled data
*
Represents p-value < 0.05
GRC-MD1: Visit 2: Better 52 (54%); Same 33 (34%); Worse 11(11%); Visit 3: Better 32 (38%); Same 38 (45%); Worse 14 (17%)
GRC-MD2: Visit 2: Better 56 (58%); Same 25 (26%); Worse 15 (16%); Visit 3: Better 36 (43%); Same 34 (40%); Worse 14 (17%)