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. 2016 Apr 25;35(46):5953–5962. doi: 10.1038/onc.2016.128

Figure 1.

Figure 1

IFNα and MSCs synergistically inhibit tumor growth. (a, b) B16F0 melanoma cells (1 × 106/25 μl) with or without IFNα (5 μg), MSC-GFP or MSC-IFNα (1 × 106/25 μl) were inoculated into C57BL/6 mice (a) or NOD-SCID mice (b) intramuscularly. After 12 days, tumors were excised and weighed. (c) MSCs were primed with IFNα for 24 h, and then cytokines were washed away. C57BL/6 mice were intramuscularly co-injected with IFNα-primed MSCs (1 × 106/thigh) and B16F0 melanoma cells (1 × 106/thigh). After 14 days, mice were killed and tumors were excised and weighed. All values represent means±s.d. Experiments were repeated at least twice. ns, not significant; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001.